Research associate
2012
I am particularly interested in biological applications of foldamers.
My research is focused on exploring protein surface recognition by synthetic organic molecules and in particular foldamers that are non-natural oligomers with predictable and well characterized folding patterns. The challenge is to understand how completely different molecules by nature with different “langages” can interact with each other and thus design new inhibitors of protein-protein interactions (PPI).
2017
Member of the BISE team
Institute of Chemistry and Biology of Memebranes and Nanoobjects, Bordeaux, France, working on protein targeting with oligoamide aromatic foldamers
2016
CR1
(CNRS research associate)
Working on protein surface recognition by oligoamide aromatic foldamers
2012 – 2016
CR2
(CNRS research associate)
In Ivan Huc team at the European Institute of Chemistry and Biology (IECB), Bordeaux, France, working on protein surface recognition by oligoamide aromatic foldamers
2010 – 2012
Post-Doctoral fellow
Gilles Guichard team at the European Institute for Chemistry and Biology, Bordeaux, France, working on molecular recognition and organocatalysis with oligourea foldamers
2008 – 2009
Post-Doctoral fellow
Yitzhak Tor at UCSD, San Diego, USA, working on cellular uptake of guanidinoglycosides derivatives
2004 – 2008
PhD Thesis
Gilles Guichard team at IBMC, Strasbourg, France, working on the structural properties of urea-based peptidomimetics
2005
M. Sc.
Pharmacology and pharmacochemsitry at University of Strasbourg, France
2004
M. Sc.
Chemistry, at the The European Engineering school of Chemistry, Polymers and Materials Science (ECPM) in Strasbourg
Recent selected publications
- Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries; M. Jewginski, T. Granier, B. Langlois d’Estaintot, L. Fischer, C. D. Mackereth, I. Huc; J. Am. Chem. Soc. 2017, 139, 2928-2931.
- Solution observation of dimerization and helix handedness induction in a human carbonic anhydrase–helical aromatic amide foldamer complex; M. Jewginski, L. Fischer, C. Colombo, I. Huc, C. D. Mackereth, ChemBioChem, 2016, 17, 727-736.
- Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 A resolution; J. Buratto, C. Colombo, M. Stupfel, S. J. Dawson, C. Dolain, B. Langlois d’Estaintot, L. Fischer, T. Granier, M. Laguerre, B. Gallois, I. Huc Angew. Chem. Int. Ed. 2014, 53, 883-887.