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Lucile Fischer

Research associate


I am particularly interested in biological applications of foldamers.

My research is focused on exploring protein surface recognition by synthetic organic molecules and in particular foldamers that are non-natural oligomers with predictable and well characterized folding patterns. The challenge is to understand how completely different molecules by nature with different “langages” can interact with each other and thus design new inhibitors of protein-protein interactions (PPI).


Member of the BISE team

Institute of Chemistry and Biology of Memebranes and Nanoobjects, Bordeaux, France, working on protein targeting with oligoamide aromatic foldamers



(CNRS research associate)

Working on protein surface recognition by oligoamide aromatic foldamers

2012 – 2016


(CNRS research associate)

In Ivan Huc team at the European Institute of Chemistry and Biology (IECB), Bordeaux, France, working on protein surface recognition by oligoamide aromatic foldamers

2010 – 2012

Post-Doctoral fellow

Gilles Guichard team at the European Institute for Chemistry and Biology, Bordeaux, France, working on molecular recognition and organocatalysis with oligourea foldamers

2008 – 2009

Post-Doctoral fellow

Yitzhak Tor at UCSD, San Diego, USA, working on cellular uptake of guanidinoglycosides derivatives

2004 – 2008

PhD Thesis

Gilles Guichard team at IBMC, Strasbourg, France, working on the structural properties of urea-based peptidomimetics


M. Sc.

Pharmacology and pharmacochemsitry at University of Strasbourg, France


M. Sc.

Chemistry, at the The European Engineering school of Chemistry, Polymers and Materials Science (ECPM) in Strasbourg

Recent selected publications

  • Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries; M. Jewginski, T. Granier, B. Langlois d’Estaintot, L. Fischer, C. D. Mackereth, I. Huc;  J. Am. Chem. Soc. 2017139, 2928-2931.
  • Solution observation of dimerization and helix handedness induction in a human carbonic anhydrase–helical aromatic amide foldamer complex; M. Jewginski, L. Fischer, C. Colombo, I. Huc, C. D. Mackereth, ChemBioChem201617, 727-736.
  • Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 A resolutionJ. Buratto, C. Colombo, M. Stupfel, S. J. Dawson, C. Dolain, B. Langlois d’Estaintot, L. Fischer, T. Granier, M. Laguerre, B. Gallois, I. Huc Angew. Chem. Int. Ed. 2014, 53, 883-887.